ROY LAB NEWS
NEW SCOPE ARRIVES
Our new workhorse Leica DM6 fluorescent scope was installed this week. It replaces our well-loved Leica DMRA, which served us well for 19 years!
SAVINA PUBLISHES IN JOVE
Savina Cammalleri, a third year undergraduate student in the Roy Lab, published her first paper! Together with the help of Jess Knox, Savina successfully answered the call from JOVE for nematode-related culturing manuscripts. Congrats Savina! We are hugely proud of you.
Update: Our department recently featured Savina in an exciting press release. Read the article here.
Cammalleri, S. R., Knox, J., and Roy, P.J. 2022. Culturing and Screening the Plant Parasitic Nematode Ditylenchus dipsaci. J. Vis. Exp. (179), e63438, doi:10.3791/63438.
SEAN SUCCESSFULLY DEFENDS HIS PHD!
Like there was ever any doubt, Roy Lab PhD candidate Sean Harrington successfully defended his PhD earlier this week. It was clear that Sean impressed the examining committee with not only a beautiful thesis with tons of new discoveries, but his mastery of the subject matter as well. A big thanks to Raffi Aroian (UMASS) for serving as Sean's external examiner. Congrats Sean! Well deserved!
Harrington, S. Exploiting Caenorhabditis elegans as a Discovery Platform to Identify Nematode Parasiticides that act Through Neuromuscular Disruption. 2022.
SAVINA WINS BEST ABSTRACT PRIZE
Savina Cammalleri, a second year undergraduate in the Roy Lab, wins the Donnelly Summer Research, 'Best Abstract' Prize. Bravo Savina!!!
Cammalleri, S. R., Knox, J., Burns, A.R., and Roy, P.J. Identification of Novel Nematicides to Combat Plant-Parasitic Nematodes. Donnelley Centre Summer Student Mini Symposium.
JESS PUBLISHES IN SCIENTIFIC REPORTS
In a manuscript that is as beautiful as it is insightful, Jess publishes her kinase inhibitor survey in Scientific Reports. Jess's paper surveys 2040 inhibitors of vertebrate kinases to identify those that inhibit nematode orthologs. Of these, she used sequence analyses to determine which inhibitors have potential to be developed into selective nematicides. Beautiful work Jess!
Knox, J., Joly. N., Linossi, E. M., Carmona-Negrón, J.A., Jura, N., Pintard, L., Zuercher, W., and Roy, P.J. 2021. A Survey of the Kinome Pharmacopeia Reveals Multiple Scaffolds and Targets for the Development of Novel Anthelmintics. Scientific Reports. 11:9161
MUNTASIR PUBLISHES IN NATURE COMMUNICATIONS
Muntasir, a Roy Lab PhD student, began his PhD with the ambition of understanding a phenomenon that has long popped up in our drug screens- some molecules visibly accumulate in the heads of worms. This paper shows that a lipid synthesis pathway is key in facilitating small molecule crystallization in the animals and is the first of several that Muntasir is planning. Really great work Muntasir!
Kamal, M., Moshiri, H., Magomedova, L., Han, D., Nguyen, K.C.Q., Yeo, M., Knox, J., Bagg, R., Won, A.M., Szlapa, K., Yip, C., Cummins, C.L., Hall, D.H., and Roy, P.J. 2019. The Marginal Cells of the Caenorhabditis elegans Pharynx Scavenge Cholesterol and Other Hydrophobic Small Molecules. Nature Communications. 10, 1-16.
JESSICA KNOX WINS TOP PHD STUDENT AWARD
Jessica Knox, PhD Student in the Roy Lab, wins the Donnelly Centre's Jennifer Dorrington Award ($2K cash prize) for Top PhD Student. Read more here. Well deserved Jess!
PETER LANDS CIHR GRANT
With heavy input from multiple members of the Roy Lab, including Sean Harrington and Jacob Pyche, Peter Lands a new five year CIHR grant, "The Development of Novel Neuroactive Compounds to Combat Parasitic Nematodes". Thanks to all Roy Lab members for making valuable contributions.
ANDREW NAGS AN NSERC I2I GRANT
In a grant written without much help from others, Roy Lab Research Associate Andrew Burns lands an NSERC i2i Commercialization Grant, 'Novel Nematicidal Agents to Improve Crop Production'. Fantastic Job Andrew (as always)!!!
PETER AND CAROLYN CUMMINS WIN LOCAL RESEARCH AWARD
Long-time collaborators Peter Roy and Carolyn Cummins win the Leslie Dan Faculty of Pharmacy New Initiative and Innovation Award. The project is focused on identifying drugs to suppress the childhood liver disease PFIC3.
JESS WINS NSERC ALEXANDER GRAHAM BELL CANADA GRADUATE SCHOLARSHIP
Jess, a PhD student in the Roy Lab, wins a three year NSERC Alexander Graham Bell Canada Doctoral Scholarship. Way to go Jess!
JACK WINS BEST POSTER AWARD
Jack Daiyang Li, a third year undergraduate in the Roy Lab, wins best poster presentation award at the Donnelly's annual summer student research symposium. Fantastic Work Jack! We know you are going places!
Jack Daiyang Li, Sean Harrington, Andrew Burns, Jessica Knox & Peter Roy. A Systematic Survey of Potential Interactions between Novel Lead Nematicides and Commercial Nematicides. Donnelly Undergraduate Summer Student Symposium.
SEAN WINS TOP TALK PRIZE
At the Toronto Visions in Pharmacology Symposium, Sean gets the Top Prize for his talk, 'Developing New Drugs to Clear Parasitic Worm Infections'. Great work Sean!
EMILIE WINS TOP POSTER PRIZE
Emilie, an MSc student in the Roy Lab, wins the top poster prize at the Anthelmintic III conference in Indian Rocks Beach in sunny Florida! Congrats Emilie!