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at the University of Toronto
RECENT PAPERS... AND SOME OF OUR CLASSICS
HARRINGTON S*, PYCHE J*, BURNS AR, SPALHOLZ T, BAKER RJ, CHING J, LAUTENS M, KULKE D, DEUTHER-CONRAD W, BRUST P, AND ROY PJ. 2022. NEMACOL IS A SMALL MOLECULE INHIBITOR OF C. ELEGANS VESICULAR ACETYLCHOLINE TRANSPORTER WITH ANTHELMINTIC POTENTIAL. PRE-PRINT ON BIORXIV.
DOI: HTTPS://DOI.ORG/10.1101/2022.03.12.484074
June 17, 2022
ROY PJ. 2022. TEMPORAL REGULATION OF GENE EXPRESSION IN POST-MITOTIC CELLS IS REVEALED FROM A SYNCHRONIZED POPULATION OF C. ELEGANS LARVAE. MICROPUBLICATION BIOLOGY. 10.17912/MICROPUB.BIOLOGY.000587.
June 10, 2022
BURNS AR, ROSS R, KITNER M, VOLPATTI J, VAIDYA AS, PUUMALA E, PALMEIRA BM, REDMAN EM, SNIDER J, MARWAH S, CHUNG S, MACDONALD MH, TIEFENBACH J, HU C, XIAO Q, FINNEY CAM, KRAUSE HM, MACPARLAND S, STAGLJAR I, GILLEARD JS, COWEN LE, MEYER S, CUTLER SR, DOWLING JJ, LAUTENS M, ZASADA I, ROY PJ. SELECTIVE CONTROL OF PARASITIC NEMATODES USING BIOACTIVATED NEMATICIDES.
Submitted for peer-review.
Read the Pre-Print HERE
KAMAL, M., KNOX, J., HAN, D., BURNS, A. R., NGUYEN, K.C.Q., HALL, D.H., AND ROY, P.J. PHARMACOLOGICAL INTERROGATION OF THE C. ELEGANS PHARYNGEAL CUTICLE REVEALS SMALL MOLECULE AMYLOID DISRUPTORS.
This is a companion manuscript that extends the results of our recent Kamal, Tokmakjian, and Knox manuscript that has recently been submitted for peer review.
Read the Pre-Print HERE
KAMAL, M.*, TOKMAKJIAN, L.*, KNOX, J.J.*, MASTRANGELO, P., JI, J., CAI, H., WOJCIECHOWSKI, J.W., HUGHES, M.P., TAKÁCS, K., CHU, X., PEI, J., GROLMUSZ, V., KOTULSKA, M., FORMAN-KAY, J.D., AND ROY, P.J. A SPATIOTEMPORAL RECONSTRUCTION OF THE C. ELEGANS PHARYNGEAL CUTICLE REVEALS A STRUCTURE RICH IN PHASE-SEPARATING PROTEINS.
Submitted for peer-review.
Read the Pre-Print HERE
SEAN HARRINGTON, JESSICA J. KNOX, ANDREW R. BURNS, KEN LOON-CHOO, AARON AU, MEGAN KITNER, CECILE HAEBERLI, JACOB PYCHE, CASSANDRA D’AMATA, YONG-HYUN KIM JONATHAN R. VOLPATTI, MAXIMILLANO GUILIANI, JAMIE SNIDER, VICTORIA WONG, BRUNA M. PALMEIRA, ELIZABETH M. REDMAN, ADITYA S. VAIDYA, JOHN GILLEARD, IGOR STAGLJAR, SEAN R. CUTLER, DANIEL KULKE, JAMES J. DOWLING, CHRISTOPHER M. YIP, JENNIFER KEISER, INGA ZASADA, MARK LAUTENS, AND PETER J. ROY. A NEMATODE-SELECTIVE POTENTIATOR OF ORGANOPHOSPHATE AND CARBAMATE AGROCHEMICALS.
Submitted for Peer Review.
Read the Pre-Print HERE
Watch the effects of Nementin on worms by checking out the video HERE.
MURAREANU, B.M., KNOX, J., ROY, P.J., AND A. W. REINKE. HIGH-THROUGHPUT SMALL MOLECULE SCREEN IDENTIFIES INHIBITORS OF MICROSPORIDIA INVASION AND PROLIFERATION IN C. ELEGANS.
Submitted for peer-review.
Read the Pre-print HERE
CAMMALLERI, S. R., KNOX, J., AND ROY, P.J. 2022. CULTURING AND SCREENING THE PLANT PARASITIC NEMATODE DITYLENCHUS DIPSACI. J. VIS. EXP. (179), E63438
Read the Paper HERE
KNOX, J., JOLY. N., LINOSSI, E. M., CARMONA-NEGRÓN, J.A., JURA, N., PINTARD, L., ZUERCHER, W., AND ROY, P.J. 2021. A SURVEY OF THE KINOME PHARMACOPEIA REVEALS MULTIPLE SCAFFOLDS AND TARGETS FOR THE DEVELOPMENT OF NOVEL ANTHELMINTICS. SCIENTIFIC REPORTS. 11:9161
Read the Paper HERE
VOLPATTI, J., ENDO, Y., KNOX, J., GROOM, L., BRENNAN, S., NOCHE, R., NOCHE, R., ZUERCHER, W., ROY, P., DIRKSEN, R. T., AND DOWLING, J.J. 2020. IDENTIFICATION OF DRUG MODIFIERS FOR RYR1 RELATED MYOPATHY USING A MULTI-SPECIES DISCOVERY PIPELINE. ELIFE 2020;9:E57481
Read the Paper HERE
KAMAL, M., MOSHIRI, H., MAGOMEDOVA, L., HAN, D., NGUYEN, K.C.Q., YEO, M., KNOX, J., BAGG, R., WON, A.M., SZLAPA, K., YIP, C., CUMMINS, C.L., HALL, D.H., AND ROY, P.J. 2019. THE MARGINAL CELLS OF THE CAENORHABDITIS ELEGANS PHARYNX SCAVENGE CHOLESTEROL AND OTHER HYDROPHOBIC SMALL MOLECULES. NATURE COMMUNICATIONS. 10, 1-16.
Read the Paper HERE
OTTEN, C., KNOX, J., BOULDAY, G., EYMERY, M., HANISZEWSKI, M., NEUENSCHWANDER,M., RADETZKI, S., VOGT, I, HÄHN, T., DE LUCA, C., CARDOSO, C., HAMAD, S., GIL, C., I., ROY, P., ALBIGES-RIZO, C., FAUROBERT, C., VON KRIES, J.P., CAMPILLOS, M., TOURNIER-LASSERVE, E., DERRY, W.B., AND ABDELILAH-SEYFRIED, S. 2018. NOVEL MOLECULAR PATHWAYS INVOLVED IN CEREBRAL CAVERNOUS MALFORMATIONS UNCOVERED BY SYSTEMATIC PHARMACOLOGICAL SUPPRESSION. EMBO MOL MEDICINE, 10(10). PII: E9155.
Read the Paper HERE
BURNS, A.R., BAGG, R., YEO, M., LUCIANI, G.M., SCHERTZBERG, M., FRASER, A.G., AND ROY, P.J. 2017. THE NOVEL NEMATICIDE WACT-86 INTERACTS WITH ALDICARB TO KILL NEMATODES. PLOS NEGLECTED TROPICAL DISEASES. 11(4): E0005502
Read the Paper HERE
BURNS, A.R., LUCIANI, G.M., MUSSO, G., BAGG, R., YEO, M., ZHANG, Y., RAJENDRAN, L., GLAVIN, J., HUNTER, R., REDMAN, E., STASIUK, S., SCHERTZBERG, M., MCQUIBBAN, G.A., CAFFREY, C.R., CUTLER, S., R., TYERS, M., GIAEVER, G., NISLOW, C., FRASER, A.G., MACRAE, C. A., GILLEARD, J. AND ROY, P.J. 2015. CAENORHABDITIS ELEGANS IS A USEFUL MODEL FOR ANTHELMINTIC DISCOVERY. NATURE COMMUNICATIONS. 6:7485
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BURNS, A.R., WALLACE, I.M., WILDENHAIN, J., TYERS, M., GIAEVER, G., BADER, G., NISLOW, C., CUTLER, S.R., AND ROY, P.J. 2010. A PREDICTIVE MODEL FOR DRUG BIOACCUMULATION AND BIOACTIVITY IN CAENORHABDITIS ELEGANS. NATURE CHEMICAL BIOLOGY, 6, P549-557
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LUCIANI, G.M., MAGOMEDOVA, L., PUCKRIN, R., URBANUS, M., L., WALLACE, I.M., GIAEVER, G., NISLOW, C., CUMMINS, C.L. §, AND ROY, P.J. 2011. DAFADINE INHIBITS DAF-9 TO PROMOTE DAUER-FORMATION AND LONGEVITY OF CAENORHABDITIS ELEGANS. NATURE CHEMICAL BIOLOGY 7, 891-893
Read the Paper HERE
KWOK, T., RICKER, N., FRASER, R., CHAN, A., BURNS, A., STANLEY, E.F., MCCOURT, P., CUTLER, S., AND ROY, P.J. 2006. A SMALL MOLECULE SCREEN IN C. ELEGANS YIELDS A NEW CALCIUM CHANNEL ANTAGONIST. NATURE. 441, 91-95.
Read the Paper HERE
Publications: Publications
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